1. Spike is made of medical grade ABS,protective cap is made of polyethylene.Pyrogen-free,Toxic-free,BPA free,DEHP free.Sterilized by EO gas. 2. Fits into rubber stoppers 6.3 mm and bag set ports. 3. Allows easy flow even with non-evacuated glass vials. 4. Large internal diameter. 5. Provides secure connection of two containers. 6. Large grip flanges.